Search on: 2 ISOPROPYLMALATE SYNTHASE 
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Descriptor English:   2-Isopropylmalate Synthase 
Descriptor Spanish:   2-Isopropilmalato Sintasa 
Descriptor Portuguese:   2-Isopropilmalato Sintase 
Synonyms English:   2 Isopropylmalate Synthase
Synthase, 2-Isopropylmalate
Synthase, alpha-Isopropylmalate
alpha Isopropylmalate Synthase
alpha-Isopropylmalate Synthase  
Tree Number:   D08.811.913.050.614
Definition English:   An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12. 
History Note English:   91(75); was see under KETOACID-LYASES 1975-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   7712 
Unique Identifier:   D015079 

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